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One more research grant for Ulf Strömberg

News: Nov 29, 2017

Ulf Strömberg, guest professor at Health Metrics, has received one more positive grant decision this fall, this time from the Swedish Cancer Society. Earlier this fall, Ulf Strömberg received a research grant from Forte. “Very exciting, we are very happy and grateful to be able to carry out this research project” says Ulf.

The research project aims to develop new statistical methods to analyze participation in populationbased screening studies, and to assess the importance of variation in participation across population groups.

Overall participation rate and selection effects, related to risk differences between participants and non-participants, influence the effectiveness of a cancer screening program. Neighborhood area can impose a contextual effect on participation, i.e. beyond the effects conferred by individual-level characteristics. If such geographic disparities in participation is supported by a complete analysis taking into account both individual factors and residential area, investigators may suggest targeted interventions aimed at improving uptake in disadvantaged neighborhoods. Investigators need analytic tools to project effects of potential interventions. National collaboration enable us to analyze participation and selection effects in the ongoing population-based study on alternative screening procedures for colorectal cancer, SCREESCO (SCREEning of Swedish COlons; colonoscopy direct vs. immunological fecal-Hb test followed by colonoscopy).

The research project will
● develop hierarchical Bayes models for assessing neighborhood- and individual-level disparities in participation;
● develop statistical methods for sensitivity analysis addressing uncontrolled individual-level confounding across neighborhoods;
● develop statistical methods for detecting varying geographic patterns of participation rates between alternative screening procedures;
● analyze uptake in SCREESCO;
● propose analytic strategies to assess selection effects related to socio-demographic and geographic disparities in the uptake of a screening program;
● demonstrate how potential, targeted interventions that modify the uptake of a screening program for colorectal cancer might influence selection effects, effectiveness and health economic evaluations (cost-effectiveness).

Implications from the project might promote participation in high-risk groups and more equal use of health care resources.


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